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Invitrogen

Phospho-TBK1 (Ser172) Polyclonal Antibody

Advanced Verification
1 Published Figure
2 References
View all (32) TBK1 antibodies

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Phospho-TBK1 (Ser172) Polyclonal Antibody

Product Details

PA5-105919

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TBK1(Accession Q9UHD2), corresponding to amino acid residues around phosphorylated Ser172.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817318

Product Specific Information

Antibody detects endogenous levels of TBK1 only when phosphorylated at Ser172.

Target Information

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; protein kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk; unnamed protein product

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Gene Aliases: 1200008B05Rik; AI462036; AIARV; AW048562; FTDALS4; IIAE8; NAK; T2K; TBK1

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UniProt ID: (Human) Q9UHD2, (Mouse) Q9WUN2

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Entrez Gene ID: (Human) 29110, (Mouse) 56480, (Rat) 299827

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Function(s)
nucleotide binding nucleic acid binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein phosphatase binding identical protein binding phosphoprotein binding RNA polymerase II sequence-specific DNA binding transcription factor binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
cytoplasmic translation activation of innate immune response immune system process cytoplasmic pattern recognition receptor signaling pathway protein phosphorylation protein import into nucleus inflammatory response I-kappaB kinase/NF-kappaB signaling mRNA transcription response to virus regulation of gene expression positive regulation of autophagy negative regulation of gene expression macroautophagy positive regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of metabolic process signal transduction involved in regulation of gene expression cellular response to nutrient levels positive regulation of TOR signaling regulation of type I interferon production negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production toll-like receptor 4 signaling pathway TORC1 signaling TORC2 signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein kinase B signaling dendritic cell proliferation innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation defense response to Gram-positive bacterium defense response to virus positive regulation of protein kinase B signaling type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway T follicular helper cell differentiation defense response to other organism antiviral innate immune response cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of TORC1 signaling positive regulation of TORC1 signaling positive regulation of xenophagy positive regulation of TORC2 signaling phosphorylation positive regulation of interferon-beta biosynthetic process
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