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Invitrogen

Phospho-Annexin A1 (Tyr21) Polyclonal Antibody

View all (72) Annexin A1 antibodies

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Phospho-Annexin A1 (Tyr21) Polyclonal Antibody

Product Details

PA5-105965

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ANXA1(Accession P04083), corresponding to amino acid residues around phosphorylated Tyr21.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817364

Product Specific Information

Antibody detects endogenous levels of Annexin A1 only when phosphorylated at Tyr21.

Target Information

Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANAX1; Annexin 1 (p35) (Lipocortin 1); Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; epididymis secretory sperm binding protein; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1; unnamed protein product

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Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1; p35

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UniProt ID: (Human) P04083, (Mouse) P10107, (Rat) P07150

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Entrez Gene ID: (Human) 301, (Mouse) 16952, (Rat) 25380

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Function(s)
phosphatidylserine binding phospholipase inhibitor activity receptor binding calcium ion binding protein binding phospholipid binding calcium-dependent phospholipid binding lipid binding phospholipase A2 inhibitor activity metal ion binding calcium-dependent protein binding cadherin binding involved in cell-cell adhesion single-stranded DNA binding single-stranded RNA binding helicase activity structural molecule activity protein binding, bridging double-stranded DNA-dependent ATPase activity annealing helicase activity protein homodimerization activity calcium-binding protein
Process(es)
neutrophil homeostasis adaptive immune response immune system process monocyte chemotaxis regulation of leukocyte migration phagocytosis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of cell shape myoblast migration involved in skeletal muscle regeneration peptide cross-linking actin cytoskeleton organization keratinocyte differentiation positive regulation of vesicle fusion regulation of interleukin-1 production negative regulation of interleukin-8 production positive regulation of interleukin-2 production positive regulation of neutrophil apoptotic process cellular response to vascular endothelial growth factor stimulus positive regulation of T cell proliferation neutrophil activation regulation of cell proliferation negative regulation of apoptotic process innate immune response positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of exocytosis alpha-beta T cell differentiation regulation of hormone secretion arachidonic acid secretion regulation of inflammatory response negative regulation of transport positive regulation of multicellular organismal process cellular response to glucocorticoid stimulus granulocyte chemotaxis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of wound healing neutrophil clearance cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle DNA strand renaturation insulin secretion positive regulation of prostaglandin biosynthetic process DNA duplex unwinding DNA rewinding positive regulation of apoptotic process negative regulation of protein secretion cellular response to hydrogen peroxide prolactin secretion negative regulation of phospholipase A2 activity negative regulation of interleukin-8 secretion response to hormone response to X-ray response to organic cyclic compound prostate gland development endocrine pancreas development response to corticosteroid response to estradiol gliogenesis response to drug response to peptide hormone estrous cycle response to glucocorticoid hepatocyte differentiation response to interleukin-1
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