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Invitrogen
eIF2b gamma Polyclonal Antibody
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FIGURE: 1 / 4
eIF2b gamma Antibody (PA5-106759) in ICC/IF
Immunocytochemistry analysis of eIF2b gamma in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with eIF2b gamma polyclonal antibody (Product # PA5-106759) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugat... View More
Product Details
PA5-106759
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EIF2B3(Accession Q9NR50), corresponding to amino acid residues F266-L316.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total EIF2B3.
Target Information
EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma; EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; eukaryotic translation initiation factor EIF2Bgamma; guanine nucleotide exchange factor; translation initiation factor eIF-2B subunit gamma; Translation initiation factor eIF2B subunit gamma; unnamed protein product
Gene Aliases: 1190002P15Rik; EIF-2B; EIF2B3; EIF2Bgamma; VWM3
UniProt ID: (Human) Q9NR50
Entrez Gene ID: (Human) 8891, (Mouse) 108067
cytoplasmic translational initiation
translation
translational initiation
central nervous system development
response to heat
response to glucose
oligodendrocyte development
response to peptide hormone
T cell receptor signaling pathway
regulation of translation
negative regulation of translational initiation in response to stress
positive regulation of GTPase activity
cellular response to stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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