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          • Primary Antibodies ›
          • Rho Pan Antibodies

          Invitrogen

          Rho Pan Polyclonal Antibody

          View all (4) Rho Pan antibodies

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          Cite Rho Pan Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (2)
          Rho Pan Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          Rho Pan Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          Rho Pan Antibody (PA5-106862) in IHC (P)

          Immunohistochemistry analysis of Rho Pan in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Rho Pan polyclonal antibody (Product # PA5-106862) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Rho Pan Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Rho Pan Antibody in Western Blot (WB)
          Rho Pan Polyclonal Antibody

          Product Details

          PA5-106862

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human RHOC(Accession P08134), corresponding to amino acid residues K162-L193.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2854526

          Product Specific Information

          Antibody detects endogenous levels of total RHOC.

          Target Information

          This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Aplysia ras-related homolog 12; Aplysia RAS-related homolog 6; aplysia ras-related homolog 9 (RhoC); aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; aplysia ras-related homolog B; ARHB; ARHC; epididymis secretory protein Li 42; epididymis secretory sperm binding protein; h12; h6; h9; induced in fatty liver dystrophy 1; oncogene RHO H12; oncogene RHO H6; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog 9 (RhoC); ras homolog A1; ras homolog A2; ras homolog B; ras homolog family member F (in filopodia); ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member AB; ras homolog gene family, member B; ras homolog gene family, member C; ras homolog gene family, member F (in filopodia); ras homolog gene family, member Q; ras-like protein; Ras-like protein family member 7A; Ras-like protein TC10; RAS-like, family 7, member A; ras-related GTP-binding protein TC10; RAS-related homolog 9; Rho cDNA clone 12; Rho cDNA clone 6; Rho cDNA clone 9; rho family; Rho family GTPase; Rho family GTPase Rif; Rho in filopodia; rho protein; Rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; Rho-related GTP-binding protein RhoF; Rho-related GTP-binding protein RhoQ; rhoB; rhoC GTPase; SIG-61; Silica-induced gene 61 protein; small GTP binding protein; small GTP binding protein RhoA; small GTP binding protein RhoC; small GTPase Tc10; Transforming protein RhoA; unnamed protein product

          View more View less

          Gene Aliases: AA017882; AI324259; AI845056; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; ARHF; ARHQ; AV026554; EDFAOB; H9; HEL-S-42; Ifld1; MST081; MSTP081; RASL7A; RHO12; RHOA; RHOB; RHOC; RHOF; RHOH12; RHOH6; RHOH9; RHOQ; RIF; TC10; TC10A

          View more View less

          UniProt ID: (Human) P61586, (Human) P62745, (Human) P08134, (Human) Q9HBH0, (Human) P17081, (Mouse) Q9QUI0, (Rat) P61589, (Mouse) P62746, (Rat) P62747, (Mouse) Q62159, (Mouse) Q8BYP3, (Mouse) Q8R527, (Rat) Q9JJL4

          View more View less

          Entrez Gene ID: (Human) 387, (Human) 388, (Human) 389, (Human) 54509, (Human) 23433, (Mouse) 11848, (Rat) 117273, (Mouse) 11852, (Rat) 64373, (Mouse) 11853, (Rat) 295342, (Rat) 690130, (Mouse) 23912, (Mouse) 104215, (Rat) 85428

          View more View less

          Function(s)
          nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity myosin binding protein kinase binding GDP binding guanyl-nucleotide exchange factor activity profilin binding GBD domain binding protein domain specific binding Rho GDP-dissociation inhibitor binding signal transducer activity small GTPase
          Process(es)
          mitotic cytokinesis cell morphogenesis neuron migration kidney development angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure alpha-beta T cell lineage commitment regulation of systemic arterial blood pressure by endothelin aortic valve formation regulation of transcription from RNA polymerase II promoter cytoskeleton organization cell adhesion cell-matrix adhesion small GTPase mediated signal transduction Rho protein signal transduction skeletal muscle tissue development negative regulation of cell-substrate adhesion regulation of neuron projection development cell migration substantia nigra development cerebral cortex cell migration forebrain radial glial cell differentiation actin cytoskeleton organization cell differentiation regulation of cell migration positive regulation of cell migration androgen receptor signaling pathway cytoplasmic microtubule organization positive regulation of cytokinesis regulation of actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cell junction assembly substrate adhesion-dependent cell spreading Roundabout signaling pathway cleavage furrow formation apolipoprotein A-I-mediated signaling pathway odontogenesis positive regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly apical junction assembly beta selection endothelial cell migration ossification involved in bone maturation wound healing, spreading of cells establishment of epithelial cell apical/basal polarity positive regulation of neuron differentiation negative regulation of cell size positive regulation of alpha-beta T cell differentiation negative chemotaxis cell division positive regulation of stress fiber assembly regulation of focal adhesion assembly Wnt signaling pathway, planar cell polarity pathway positive regulation of lipase activity bone trabecula morphogenesis regulation of microtubule cytoskeleton organization cellular response to lipopolysaccharide cellular response to cytokine stimulus semaphorin-plexin signaling pathway positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity negative regulation of cell migration involved in sprouting angiogenesis mitotic spindle assembly negative regulation of oxidative phosphorylation motor neuron apoptotic process endothelial tube lumen extension regulation of modification of postsynaptic structure positive regulation of NIK/NF-kappaB signaling skeletal muscle satellite cell migration negative regulation of reactive oxygen species biosynthetic process mitotic cleavage furrow formation positive regulation of vascular smooth muscle contraction positive regulation of leukocyte adhesion to vascular endothelial cell regulation of modification of postsynaptic actin cytoskeleton cellular response to chemokine regulation of neural precursor cell proliferation positive regulation of T cell migration negative regulation of motor neuron apoptotic process angiogenesis intracellular protein transport apoptotic process actin filament organization signal transduction endosome to lysosome transport positive regulation of endothelial cell migration protein transport negative regulation of cell migration positive regulation of apoptotic process positive regulation of angiogenesis negative regulation of cell cycle endothelial tube morphogenesis cellular response to hydrogen peroxide cellular response to ionizing radiation positive regulation of protein complex assembly regulation of small GTPase mediated signal transduction endocytosis insulin receptor signaling pathway regulation of cell shape establishment of cell polarity cortical actin cytoskeleton organization cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter GTP metabolic process positive regulation of glucose import positive regulation of filopodium assembly negative regulation of protein localization to plasma membrane cell cycle integrin-mediated signaling pathway positive regulation of cell growth positive regulation of actin filament polymerization stress-activated protein kinase signaling cascade response to drug negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of smooth muscle contraction regulation of dendrite development regulation of calcium ion transport negative regulation of cell death trabecula morphogenesis response to hypoxia regulation of actin polymerization or depolymerization metabolic process response to mechanical stimulus response to glucose response to amino acid response to ethanol positive regulation of translation positive regulation of cell adhesion positive regulation of vasoconstriction neuron projection morphogenesis response to glucocorticoid cellular response to progesterone stimulus cytokinesis transport obsolete transformed cell apoptotic process multicellular organism development negative regulation of glucose import negative regulation of establishment of protein localization to plasma membrane
          It has to be done as per old AB suggested Products section.

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