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Invitrogen
KV1.1 (KCNA1) Polyclonal Antibody
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FIGURE: 1 / 4
KV1.1 (KCNA1) Antibody (PA5-109341) in IHC (P)
Immunohistochemistry analysis of KV1.1 in paraffin-embedded rat spinal cord tissue. Samples were heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4, 20 minutes) and blocked in 5% BSA (30 min, room temperature), incubated with KV1.1 polyclonal antibody (Product # PA5-109341) at a dilution of 1:200 (30 min, room temperature), and followed by HRP conjugate, DAB and hematoxylin (mounted with DPX)... View More
Product Details
PA5-109341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse KV11 aa 175-224.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Rat brain tissue lysate, rat spinal cord tissue, mouse brain tissue, A549.
Target Information
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain potassium channel protein-1; IA; MBK1; megencephaly; MGC126782; MGC138385; MKI; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; potassium voltage gated channel, shaker related subfamily, member 1; Potassium voltage-gated channel subfamily A member 1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); RBKI; RCK1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1
Gene Aliases: AEMK; AI840627; EA1; HBK1; HUK1; Kca1-1; Kcna; KCNA1; Kcpvd; KV1.1; MBK1; mceph; Mk-1; MK1; RBK1; Shak
UniProt ID: (Human) Q09470, (Mouse) P16388, (Rat) P10499
Entrez Gene ID: (Human) 3736, (Mouse) 16485, (Rat) 24520
action potential
startle response
ion transport
potassium ion transport
regulation of muscle contraction
neuroblast proliferation
brain development
cell communication by electrical coupling
magnesium ion homeostasis
neuronal action potential
hippocampus development
neuronal signal transduction
ion transmembrane transport
regulation of membrane potential
neuromuscular process
detection of mechanical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of touch
protein homooligomerization
transmembrane transport
cellular response to magnesium ion
potassium ion transmembrane transport
membrane repolarization during action potential
transport
cellular protein localization
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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