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Invitrogen
PDLIM1 Polyclonal Antibody
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Product Details
PA5-110093
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Amount
93 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal LIM domain protein 1; carboxyl terminal LIM domain protein 1; Elfin; encodes 36 kDa protein; enigma; epididymis secretory protein Li 112; LIM domain protein CLP-36; LIM protein; PDZ and LIM domain protein 1; unnamed protein product
Gene Aliases: CLIM1; CLP-36; CLP36; hCLIM1; HEL-S-112; mClim1; PDLIM1
UniProt ID: (Human) O00151, (Rat) P52944, (Mouse) O70400
Entrez Gene ID: (Human) 9124, (Rat) 54133, (Mouse) 54132
response to hypoxia
regulation of transcription from RNA polymerase II promoter
response to oxidative stress
heart development
fibroblast migration
maintenance of cell polarity
actin cytoskeleton organization
establishment or maintenance of actin cytoskeleton polarity
stress fiber assembly
positive regulation of transcription, DNA-templated
muscle structure development
cell-cell adhesion
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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