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Invitrogen
Brachyury Polyclonal Antibody
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Product Details
PA5-110455
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein containing a sequence corresponding to amino acids 226-435 of human Brachyury (NP_0031721)
Conjugate
Form
Liquid
Concentration
1.92 mg/mL
Amount
192 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HKEMMEEPGD SQQPGYSQWG WLLPGTSTLC PPANPHPQFG GALSLPSTHS CDRYPTLRSH RSSPYPSPYA HRNNSPTYSD NSPACLSMLQ SHDNWSSLGM PAHPSMLPVS HNASPPTSSS QYPSLWSVSN GAVTPGSQAA AVSNGLGAQF FRGSPAHYTP LTHPVSAPSS SGSPLYEGAA AATDIVDSQY DAAAQGRLIA SWTPVSPPSM
Target Information
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brachyury homolog; Brachyury protein; Protein T; RP11-459F1.1; T brachyury transcription factor; T, brachyury homolog; T-box transcription factor T
Gene Aliases: SAVA; T; TBXT; TFT
UniProt ID: (Human) O15178
Entrez Gene ID: (Rat) 292301, (Human) 6862
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription factor binding
molecular_function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
somitogenesis
neural plate morphogenesis
neural tube closure
heart morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
penetration of zona pellucida
mesoderm development
mesoderm migration involved in gastrulation
positive regulation of cell proliferation
anatomical structure morphogenesis
anterior/posterior pattern specification
notochord formation
reproductive process
signal transduction involved in regulation of gene expression
BMP signaling pathway
notochord development
post-anal tail morphogenesis
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system development
canonical Wnt signaling pathway
bone morphogenesis
SMAD protein signal transduction
determination of heart left/right asymmetry
cellular response to retinoic acid
mesoderm formation
cell fate specification
regulation of transcription, DNA-templated
signal transduction
anterior/posterior axis specification, embryo
positive regulation of transcription, DNA-templated
cardiac muscle cell myoblast differentiation
primitive streak formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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