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Invitrogen
USP22 Polyclonal Antibody
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FIGURE: 1 / 1
USP22 Antibody (PA5-110558) in WB
Western blot analysis of USP22 in extracts of various cell lines. Samples were incubated with USP22 Polyclonal antibody (Product # PA5-110558) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-110558
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human USP22 (NP_0560911)
Conjugate
Form
Liquid
Concentration
1.59 mg/mL
Amount
159 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TAEARKRKAK SCICHVCGVH LNRLHSCLYC VFFGCFTKKH IHEHAKAKRH NLAIDLMYGG IYCFLCQDYI YDKDMEIIAK EEQRKAWKMQ GVGEKFSTWE P
Target Information
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
Gene Aliases: KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9
Entrez Gene ID: (Human) 23326, (Rat) 303201
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
H4 histone acetyltransferase activity
hydrolase activity
enzyme binding
metal ion binding
histone H2B deubiquitinase activity
histone H2A deubiquitinase activity
molecular_function
cysteine-type endopeptidase activity
ligand-dependent nuclear receptor transcription coactivator activity
cysteine protease
G2/M transition of mitotic cell cycle
regulation of DNA repair
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
proteolysis
embryo development ending in birth or egg hatching
protein deubiquitination
positive regulation of type I interferon production
regulation of RNA splicing
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
regulation of transcription, DNA-templated
biological_process
histone ubiquitination
histone deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
histone H4 acetylation
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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