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Invitrogen
CRF Polyclonal Antibody
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Product Details
PA5-114486
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRH antibody was raised against a 16 amino acid peptide near the amino terminus of human CRH. The immunogen is located within amino acids 30 - 80 of CRH.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive controls that may be used include: Human Placenta Tissue Lysate, Human Brain Tissue Slide
Target Information
Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF; unnamed protein product
Gene Aliases: CRF; CRH; CRH1
UniProt ID: (Human) P06850
Entrez Gene ID: (Human) 1392
synaptic transmission, dopaminergic
negative regulation of systemic arterial blood pressure
glucocorticoid biosynthetic process
inflammatory response
signal transduction
chemical synaptic transmission
female pregnancy
parturition
learning or memory
steroid metabolic process
positive regulation of cell proliferation
associative learning
hormone-mediated apoptotic signaling pathway
response to xenobiotic stimulus
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of circadian sleep/wake cycle, wakefulness
regulation of serotonin secretion
diterpenoid metabolic process
hypothalamus development
lung development
adrenal gland development
negative regulation of epinephrine secretion
negative regulation of luteinizing hormone secretion
locomotory exploration behavior
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to immobilization stress
response to cocaine
negative regulation of circadian sleep/wake cycle, REM sleep
response to estrogen
response to ethanol
response to ether
response to pain
ion homeostasis
neuron apoptotic process
response to corticosterone
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
long-term synaptic potentiation
positive regulation of digestive system process
negative regulation of glucagon secretion
cellular response to cocaine
cellular response to dexamethasone stimulus
positive regulation of calcium ion import
response to alcohol
positive regulation of cAMP/PKA signal transduction
response to aldosterone
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of corticosterone secretion
positive regulation of behavioral fear response
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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