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Invitrogen
ING2 Polyclonal Antibody
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FIGURE: 1 / 2
ING2 Antibody (PA5-114750) in ICC/IF
Immunocytochemistry analysis of ING2 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114750). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-114750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ING2(Accession Q9H160), corresponding to amino acid residues Y247-R280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ING2.
Target Information
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ING1Lp; Inhibitor of growth 1-like protein; Inhibitor of growth protein 2; p32; p33ING2; unnamed protein product
Gene Aliases: 2810011M06Rik; ING1L; ING2; Ing2b; P33ING2
UniProt ID: (Human) Q9H160, (Mouse) Q9ESK4
Entrez Gene ID: (Human) 3622, (Mouse) 69260
DNA binding
chromatin binding
protein binding
zinc ion binding
histone deacetylase regulator activity
phosphatidylinositol binding
macromolecular complex binding
metal ion binding
histone H3K4me3 reader activity
histone reader activity
protein complex binding
methylated histone binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
male meiosis I
signal transduction
spermatogenesis
spermatid development
sperm motility
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
male germ-line stem cell asymmetric division
seminiferous tubule development
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
regulation of cellular senescence
negative regulation of apoptotic signaling pathway
transcription, DNA-templated
negative regulation of cell proliferation
chromatin modification
regulation of growth
positive regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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