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Invitrogen
RPSA Polyclonal Antibody
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FIGURE: 1 / 3
RPSA Antibody (PA5-114795) in IHC (P)
Immunohistochemistry analysis of RPSA in human esophageal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114795) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-114795
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RPSA(Accession P08865), corresponding to amino acid residues V245-S295.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total 67kDa Laminin Receptor.
Target Information
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37 kDa laminin receptor precursor {ECO:0000255|HAMAP-Rule:MF_03016}; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37/67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}; 37LRP; 37LRP {ECO:0000255|HAMAP-Rule:MF_03016}; 40S ribosomal protein SA; 40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03016}; 67 kDa laminin receptor; 67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}; 67LR; 67LR {ECO:0000255|HAMAP-Rule:MF_03016}; Colon carcinoma laminin-binding protein; laminin receptor; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA); laminin receptor 1 {ECO:0000255|HAMAP-Rule:MF_03016}; laminin-binding protein; Laminin-binding protein precursor p40; laminin-binding protein precursor p40 {ECO:0000255|HAMAP-Rule:MF_03016}; LamR; lamR {ECO:0000255|HAMAP-Rule:MF_03016}; LBP/p40; LBP/p40 {ECO:0000255|HAMAP-Rule:MF_03016}; LRP/LR; LRP/LR {ECO:0000255|HAMAP-Rule:MF_03016}; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; OFA/iLRP; P40-3, functional; P40-8, functional; rssa; Small ribosomal subunit protein uS2; unnamed protein product
Gene Aliases: 37LRP; 67kDa; 67LR; AL022858; ICAS; LAMBR; Lamr; LAMR1; Lamrl1; LBP; LBP/p40; LRP; LRP/LR; MLR; NEM/1CHD4; P40; P40-3; P40-8; RPSA; SA; uS2
UniProt ID: (Human) P08865, (Rat) P38983, (Mouse) P14206
Entrez Gene ID: (Human) 3921, (Rat) 29236, (Mouse) 16785
ribosomal small subunit assembly
cytoplasmic translation
chromatin remodeling
translation
cell adhesion
viral entry into host cell
antiviral innate immune response
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA export from nucleus
single organismal cell-cell adhesion
epithelial cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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