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          • Primary Antibodies ›
          • FGFR1/FGFR2 Antibodies

          Invitrogen

          FGFR1/FGFR2 Polyclonal Antibody

          View all (7) FGFR1/FGFR2 antibodies

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          Cite FGFR1/FGFR2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          FGFR1/FGFR2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          FGFR1/FGFR2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          FGFR1/FGFR2 Antibody (PA5-115229) in WB

          Western blot analysis of FGFR1 in various samples (Lane 1: MCF7 cells (UV treatment), blocked with antigen-specific peptides, Lane 2: MCF7 cells (UV treatment), Lane 3: HeLa cells (LPS treatment), Lane 4: HeLa cells (heat shock treatment)). Samples were incubated with polyclonal antibody (Product # PA5-115229). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          FGFR1/FGFR2 Antibody in Western Blot (WB)
          FGFR1/FGFR2 Polyclonal Antibody

          Product Details

          PA5-115229

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human FGFR1(Accession P11362), corresponding to amino acid residues L443-V493.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2899865

          Product Specific Information

          Antibody detects endogenous levels of total FGFR1/2.

          Target Information

          FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: bacteria-expressed kinase; Basic fibroblast growth factor receptor 1; BEK fibroblast growth factor receptor; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD332; FGF Receptor 2; FGF receptor-1; FGF receptor-1 precursor; fgfr 1; FGFR-1; FGFR-2; FGFR1/PLAG1 fusion; FGFR2; fibroblast growth factor receptor (FGFr) transmembrane form; Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2; fibroblast growth factor receptor FGFR-1 secreted form; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; K-sam; Keratinocyte growth factor receptor; KGFR; MFR; N-sam; protein tyrosine kinase, receptor like 14; Proto-oncogene c-Fgr; Soluble KGFR; transmembrane protein tyrosine kinase; unnamed protein product

          View more View less

          Gene Aliases: AU043015; AW208770; AW556123; BBDS; BEK; bFGF-R-1; BFGFR; BFR-1; c-fgr; CD331; CD332; CEK; CEK3; CFD1; Eask; ECCL; ECT1; FGFBR; FGFR-1; Fgfr-2; Fgfr-7; FGFR1; FGFR2; Fgfr7; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; JWS; K-SAM; KAL2; KGFR; KGFRTr; KSAM; MFR; N-SAM; OGD; svs; TK14; TK25

          View more View less

          UniProt ID: (Human) P11362, (Human) P21802, (Rat) Q04589, (Mouse) P16092, (Mouse) P21803

          View more View less

          Entrez Gene ID: (Human) 2260, (Human) 2263, (Rat) 79114, (Mouse) 14182, (Mouse) 14183, (Rat) 25022

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding kinase activity transferase activity fibroblast growth factor binding SH2 domain binding identical protein binding protein homodimerization activity receptor-receptor interaction glycoprotein binding protein complex binding cell adhesion molecule binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development angiogenesis ureteric bud development in utero embryonic development organ induction neuron migration epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation protein phosphorylation brain development salivary gland morphogenesis sensory perception of sound cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation gene expression regulation of gene expression positive regulation of phospholipase activity positive regulation of macromolecule metabolic process negative regulation of gene expression regulation of phosphate transport positive regulation of neuron projection development cell migration peptidyl-tyrosine phosphorylation orbitofrontal cortex development ventricular zone neuroblast division cell projection assembly lung development embryonic limb morphogenesis midbrain development neuron projection development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus regulation of cell differentiation positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle protein autophosphorylation phosphatidylinositol-mediated signaling paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons skeletal system morphogenesis mesenchymal cell differentiation stem cell differentiation regulation of epithelial cell proliferation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vitamin D3 metabolic process diphosphate metabolic process cementum mineralization stem cell proliferation regulation of primary metabolic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation positive regulation of stem cell proliferation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand outflow tract septum morphogenesis membranous septum morphogenesis endochondral bone growth apoptotic process cell-cell signaling axonogenesis regulation of smoothened signaling pathway post-embryonic development embryonic pattern specification organ morphogenesis negative regulation of keratinocyte proliferation morphogenesis of embryonic epithelium pyramidal neuron development gland morphogenesis positive regulation of Wnt signaling pathway bone mineralization epithelial cell differentiation otic vesicle formation hair follicle morphogenesis response to lipopolysaccharide lacrimal gland development regulation of osteoblast proliferation organ growth fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow odontogenesis cell fate commitment response to ethanol regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter lung alveolus development mesodermal cell differentiation embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development reproductive structure development embryonic cranial skeleton morphogenesis epidermis morphogenesis branching morphogenesis of a nerve positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation positive regulation of cell division ventricular cardiac muscle tissue morphogenesis limb bud formation bone development bone morphogenesis branching involved in prostate gland morphogenesis bud elongation involved in lung branching lung lobe morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis prostate gland morphogenesis prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development fibroblast growth factor receptor signaling pathway involved in mammary gland specification lateral sprouting from an epithelium mammary gland bud formation epithelial cell proliferation involved in salivary gland morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in labyrinthine layer morphogenesis regulation of morphogenesis of a branching structure mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to hypoxia cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway positive regulation of vascular smooth muscle cell proliferation cranial skeletal system development positive regulation of phospholipase C activity stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration central nervous system neuron development regulation of cell proliferation negative regulation of osteoblast differentiation regulation of sensory perception of pain regulation of stem cell proliferation phosphorylation vasculogenesis involved in coronary vascular morphogenesis neuromuscular junction development negative regulation of cell proliferation regulation of cell fate commitment multicellular organism growth regulation of multicellular organism growth regulation of fibroblast growth factor receptor signaling pathway negative regulation of mitotic nuclear division synaptic vesicle transport positive regulation of smooth muscle cell proliferation epithelial cell proliferation coronal suture morphogenesis epithelial tube branching involved in lung morphogenesis regulation of branching involved in prostate gland morphogenesis endodermal digestive tract morphogenesis lens fiber cell development
          It has to be done as per old AB suggested Products section.

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