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Invitrogen
MED17 Polyclonal Antibody
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Product Details
PA5-115563
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MED17(Accession Q9NVC6), corresponding to amino acid residues E186-I236.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MED17.
Target Information
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e. g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD); cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP complex subunit 6; DRIP80; epididymis secretory sperm binding protein; Mediator complex subunit 17; Mediator of RNA polymerase II transcription subunit 17; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; Trap80; unnamed protein product; Vitamin D3 receptor-interacting protein complex 80 kDa component
Gene Aliases: 77kDa; ARC77; C330002H14Rik; CRSP6; CRSP77; DRIP77; DRIP80; MED17; SRB4; TRAP80
UniProt ID: (Human) Q9NVC6, (Mouse) Q8VCD5
Entrez Gene ID: (Human) 9440, (Mouse) 234959
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
protein ubiquitination
positive regulation of transcription elongation from RNA polymerase II promoter
somatic stem cell population maintenance
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
stem cell population maintenance
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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