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Invitrogen
ZIP1 Polyclonal Antibody
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FIGURE: 1 / 2
ZIP1 Antibody (PA5-115913) in IHC (P)
Immunohistochemistry analysis of ZIP1 in mouse testis tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115913) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC39A1(Accession Q9NY26), corresponding to amino acid residues L111-D161.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC39A1.
Target Information
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mZIP1; SLC39A1; solute carrier family 39 (zinc transporter), member 1; solute carrier family 39 (zinc transporter), member 3; Solute carrier family 39 member 1; unnamed protein product; zinc transporter 1; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; ZIP-1; Zrt- and Irt-like protein 1; ZRT/IRT-like protein 1
Gene Aliases: CGI-08; CGI-71; IRT1; SLC39A1; ZIP1; ZIRTL
UniProt ID: (Human) Q9UBI7, (Mouse) Q9QZ03
Entrez Gene ID: (Human) 27173, (Mouse) 30791, (Rat) 361986
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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