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Invitrogen
SOX18 Polyclonal Antibody
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Product Details
PA5-115951
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SOX18(Accession P35713), corresponding to amino acid residues L42-F92.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SOX18.
Target Information
SOX18 a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ragged; SOX18; SRY (sex determining region Y)-box 18; SRY-box 18; SRY-box containing gene 18; Sry-related HMG-box gene 18; Transcription factor SOX-18
Gene Aliases: AI385749; HLTRS; HLTS; Ra; Ragl; Sox-18; SOX18
UniProt ID: (Human) P35713, (Mouse) P43680
Entrez Gene ID: (Human) 54345, (Rat) 311723, (Mouse) 20672
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
transcription regulatory region DNA binding
protein heterodimerization activity
protein binding
HMG box transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
blood vessel development
vasculogenesis
in utero embryonic development
hair follicle development
vasculature development
lymph vessel development
lymphangiogenesis
heart looping
outflow tract morphogenesis
regulation of transcription, DNA-templated
heart development
tissue development
hair cycle process
embryonic heart tube development
blood vessel endothelial cell migration
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
anatomical structure formation involved in morphogenesis
stem cell fate specification
endocardium formation
lymphatic endothelial cell differentiation
endocardial cell differentiation
establishment of endothelial barrier
regulation of stem cell proliferation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
biological_process
mRNA transcription from RNA polymerase II promoter
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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