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Invitrogen
Synaptotagmin 1/2 Polyclonal Antibody
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Product Details
PA5-115993
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SYT1(Accession P21579), corresponding to amino acid residues Y283-K333.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Synaptotagmin 1/2.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ42519; Inositol polyphosphate-binding protein; IP4-binding protein; p65; synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin-1; Synaptotagmin-2; SytI; SytII; unnamed protein product
Gene Aliases: AW124717; BAGOS; CMS7; CMS7A; CMS7B; G630098F17Rik; mKIAA4194; MYSPC; P65; R74640; RATSYNII; SVP65; SYNII; SYT; SYT1; SYT2; SytI; SytII
UniProt ID: (Human) P21579, (Human) Q8N9I0, (Rat) P21707, (Mouse) P46096, (Rat) P29101, (Mouse) P46097
Entrez Gene ID: (Human) 6857, (Human) 127833, (Rat) 25716, (Mouse) 20979, (Rat) 24805, (Mouse) 20980
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
phospholipid binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
syntaxin-1 binding
syntaxin binding
clathrin binding
syntaxin-3 binding
identical protein binding
metal ion binding
protein heterodimerization activity
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
calcium ion sensor activity
molecular condensate scaffold activity
inositol 1,3,4,5 tetrakisphosphate binding
transporter activity
protein C-terminus binding
membrane trafficking regulatory protein
detection of calcium ion
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
regulation of dopamine secretion
vesicle organization
synaptic vesicle exocytosis
vesicle-mediated transport
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
cell differentiation
regulation of vesicle fusion
positive regulation of vesicle fusion
positive regulation of dopamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of synaptic transmission
protein heterooligomerization
response to calcium ion
regulation of synaptic transmission, glutamatergic
spontaneous neurotransmitter secretion
cellular response to calcium ion
synchronous neurotransmitter secretion
fast, calcium ion-dependent exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion
membraneless organelle assembly
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
calcium ion regulated exocytosis
synaptic vesicle endocytosis
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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