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Invitrogen
TLR6 Polyclonal Antibody
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FIGURE: 1 / 4
TLR6 Antibody (PA5-11601) in IHC (P)
Immunohistochemistry analysis of TLR6 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with TLR6 polyclonal antibody (Product # PA5-11601) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-11601
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 393-423 amino acids from the C-terminal region of human TLR6
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 286; CD286; Toll-like receptor 6; unnamed protein product
Gene Aliases: CD286; TLR6
UniProt ID: (Human) Q9Y2C9, (Mouse) Q9EPW9
Entrez Gene ID: (Human) 10333, (Mouse) 21899
beta-amyloid binding
transmembrane signaling receptor activity
receptor binding
protein binding
Toll-like receptor 2 binding
signaling receptor activity
diacyl lipopeptide binding
identical protein binding
protein heterodimerization activity
NAD+ nucleotidase, cyclic ADP-ribose generating
lipopeptide binding
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
response to bacterial lipoprotein
toll-like receptor 6 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of interleukin-6 biosynthetic process
nitric oxide metabolic process
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
activation of NF-kappaB-inducing kinase activity
positive regulation of gene expression
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
negative regulation of toll-like receptor 2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
defense response to bacterium
positive regulation of macrophage activation
positive regulation of nitric oxide biosynthetic process
positive regulation of inflammatory response
cellular response to oxidised low-density lipoprotein particle stimulus
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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