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Invitrogen

TRAP220 Polyclonal Antibody

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TRAP220 Polyclonal Antibody

Product Details

PA5-116067

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MED1(Accession Q15648), corresponding to amino acid residues D1007-T1057.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900701

Product Specific Information

Antibody detects endogenous levels of total TRAP220/MED1.

Target Information

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1; nuclear receptor interacting protein; p53 regulatory protein RB18A; PBP; peroxisome proliferator activated receptor binding protein; Peroxisome proliferator-activated receptor-binding protein; Ppar binding protein; PPAR-binding protein; PPARG binding protein; PPRB; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TR-interacting protein 2; Trap220; TRIP-2; unnamed protein product; vitamin D receptor-interacting protein 230 kD; Vitamin D receptor-interacting protein complex component DRIP205

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Gene Aliases: AI480703; ARC205; CRSP1; CRSP200; CRSP210; DRIP205; DRIP230; l11Jus15; MED1; PBP; PPARBP; PPARGBP; RB18A; RGD1559552; TRAP220; TRIP2

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UniProt ID: (Human) Q15648, (Mouse) Q925J9

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Entrez Gene ID: (Human) 5469, (Mouse) 19014, (Rat) 497991

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator binding DNA binding chromatin binding transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding ligand-dependent nuclear receptor binding estrogen receptor binding chromatin DNA binding histone acetyltransferase binding vitamin D receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding macromolecular complex binding thyroid hormone receptor binding LBD domain binding RNA polymerase II sequence-specific DNA binding transcription factor binding ubiquitin protein ligase activity general transcription initiation factor binding DNA-binding transcription factor binding promoter-specific chromatin binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding RNA polymerase II transcription cofactor activity receptor activity transcription factor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity protein complex binding nuclear hormone receptor binding mediator complex binding RNA metabolism protein nucleic acid metabolism protein general transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis angiogenesis in utero embryonic development liver development embryonic placenta development lens development in camera-type eye thyroid hormone mediated signaling pathway ventricular trabecula myocardium morphogenesis retinal pigment epithelium development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter thyroid hormone generation protein import into nucleus androgen biosynthetic process brain development heart development lactation positive regulation of cell proliferation organ morphogenesis positive regulation of gene expression negative regulation of keratinocyte proliferation protein ubiquitination keratinocyte differentiation monocyte differentiation intracellular steroid hormone receptor signaling pathway organ regeneration positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of intracellular estrogen receptor signaling pathway mammary gland epithelial cell proliferation embryonic heart tube development embryonic hindlimb morphogenesis embryonic hemopoiesis peroxisome proliferator activated receptor signaling pathway cellular response to hepatocyte growth factor stimulus megakaryocyte development mRNA transcription from RNA polymerase II promoter camera-type eye development negative regulation of apoptotic process G0 to G1 transition fat cell differentiation positive regulation of keratinocyte differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter erythrocyte development enucleate erythrocyte development RNA polymerase II transcriptional preinitiation complex assembly hematopoietic stem cell differentiation positive regulation of transcription initiation from RNA polymerase II promoter positive regulation of interferon-gamma-mediated signaling pathway mammary gland branching involved in thelarche mammary gland branching involved in pregnancy epithelial cell proliferation involved in mammary gland duct elongation positive regulation of G0 to G1 transition regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to steroid hormone stimulus cellular response to thyroid hormone stimulus positive regulation of hepatocyte proliferation regulation of RNA biosynthetic process transcription, DNA-templated regulation of transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter multicellular organism development androgen receptor signaling pathway positive regulation of protein import into nucleus, translocation positive regulation of mammary gland epithelial cell proliferation ERK1 and ERK2 cascade positive regulation of receptor activity
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