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Invitrogen

UBR4 Polyclonal Antibody

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UBR4 Polyclonal Antibody

Product Details

PA5-116101

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human UBR4(Accession Q5T4S7), corresponding to amino acid residues P4006-A4056.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900735

Product Specific Information

Antibody detects endogenous levels of total UBR4.

Target Information

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; N-recognin-4; p600; RBAF600; retinoblastoma-associated factor 600; retinoblastoma-associated factor 600-like protein; retinoblastoma-associated factor 600; RBAF600; Retinoblastoma-associated factor of 600 kDa; RING-type E3 ubiquitin transferase UBR4; unnamed protein product; zinc finger UBR1-type protein 1; zinc finger, UBR1 type 1; ZUBR1

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Gene Aliases: 1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; KIAA0462; KIAA1307; mKIAA0462; N28143; p600; RBAF600; UBR4; ZUBR1

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UniProt ID: (Human) Q5T4S7, (Mouse) A2AN08

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Entrez Gene ID: (Human) 23352, (Mouse) 69116, (Rat) 313658

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Function(s)
ubiquitin-protein transferase activity protein binding calmodulin binding zinc ion binding transferase activity metal ion binding ubiquitin protein ligase activity protein binding, bridging involved in substrate recognition for ubiquitination UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase
Process(es)
cytoplasmic translation translational initiation ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process fatty acid biosynthetic process response to oxidative stress endosome organization proteasomal protein catabolic process positive regulation of autophagy protein ubiquitination protein catabolic process cellular response to stress proteasome-mediated ubiquitin-dependent protein catabolic process protein K27-linked ubiquitination negative regulation of fatty acid biosynthetic process protein stabilization type I interferon signaling pathway protein K48-linked ubiquitination protein K11-linked ubiquitination protein targeting to vacuole involved in autophagy ubiquitin-dependent protein catabolic process via the N-end rule pathway cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process cytoplasm protein quality control HRI-mediated signaling negative regulation of HRI-mediated signaling protein branched polyubiquitination protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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