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Invitrogen
ZDHHC18 Polyclonal Antibody
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FIGURE: 1 / 2
ZDHHC18 Antibody (PA5-116614) in IHC (P)
Immunohistochemistry analysis of ZDHHC18 in paraffin-embedded human lung cancer. Samples were incubated with ZDHHC18 Polyclonal antibody (Product # PA5-116614) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-116614
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 301-388 of human ZDHHC18 (NP_1156591)
Conjugate
Form
Liquid
Concentration
1.399 mg/mL
Amount
139.9 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Raji, HeLa, Mouse brain, Rat brain
Immunogen sequence: YLVASNLTTN EDIKGSWSSK RGGEASVNPY SHKSIITNCC AVLCGPLPPS LIDRRGFVQS DTVLPSPIRS DEPACRAKPD ASMVGGHP
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DHHC domain-containing cysteine-rich protein 18; DHHC-18; membrane-associated DHHC18 zinc finger protein; Palmitoyltransferase ZDHHC18; unnamed protein product; Zinc finger DHHC domain-containing protein 18; zinc finger DHHC-type containing 18; zinc finger DHHC-type palmitoyltransferase 18; zinc finger, DHHC domain containing 18
Gene Aliases: DHHC-18; DHHC18; ZDHHC18
UniProt ID: (Human) Q9NUE0, (Mouse) Q5Y5T2, (Rat) Q2TGJ1
Entrez Gene ID: (Human) 84243, (Mouse) 503610, (Rat) 362613
immune system process
protein targeting to membrane
protein localization
peptidyl-L-cysteine S-palmitoylation
innate immune response
negative regulation of innate immune response
cGAS/STING signaling pathway
negative regulation of cGAS/STING signaling pathway
protein palmitoylation
cellular protein localization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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