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Invitrogen
TSN Polyclonal Antibody
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FIGURE: 1 / 4
TSN Antibody (PA5-116869) in IHC (P)
Immunohistochemistry analysis of TSN in paraffin-embedded human colon carcinoma. Samples were incubated with TSN Polyclonal antibody (Product # PA5-116869) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-116869
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide
Conjugate
Form
Liquid
Concentration
1.72 mg/mL
Amount
172 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: K-562, HeLa, Mouse spleen, Mouse brain, Rat thymus, Rat spleen
Immunogen sequence: GFQDIPKRCL KAREHFGTVK THLTSLKTKF PAEQYYRFHE HWRFVLQRLV FLAAFVVYLE TETLVTREAV TEILGIEPDR EKGFHLDVED YLSGVLILAS E
Target Information
Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3PO; Component 3 of promoter of RISC; recombination hotspot associated factor; recombination hotspot-binding protein; TB-RBP; testis brain-RNA binding protein; Testis/brain RNA-binding protein; testis/brain-RNA-binding protein; Translin; unnamed protein product
Gene Aliases: 2610034C24Rik; AU040286; BCLF-1; C3PO; RCHF1; REHF-1; TB-RBP; TBRBP; TRSLN; TSN
UniProt ID: (Human) Q15631, (Mouse) Q62348
Entrez Gene ID: (Human) 7247, (Rat) 60381, (Mouse) 22099
nucleic acid binding
DNA binding
single-stranded DNA binding
RNA binding
mRNA binding
nuclease activity
endonuclease activity
protein binding
hydrolase activity
identical protein binding
sequence-specific DNA binding
endoribonuclease activity
protein complex binding
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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