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Invitrogen
Synaptotagmin 4 Polyclonal Antibody
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FIGURE: 1 / 3
Synaptotagmin 4 Antibody (PA5-118300) in ICC/IF
Immunofluorescence staining of Synaptotagmin 4 in SHSY5Y cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Synaptotagmin 4 Polyclonal Antibody (Product # PA5-118300, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue)... View More
Product Details
PA5-118300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human SYT4 fragment
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Synaptotagmin IV; Synaptotagmin-4; Synaptotagmin4; SytIV; unnamed protein product
Gene Aliases: HsT1192; KIAA1342; SYT4
UniProt ID: (Human) Q9H2B2
Entrez Gene ID: (Human) 6860
vesicle fusion
neurotransmitter secretion
memory
positive regulation of glutamate secretion
regulation of dopamine secretion
vesicle-mediated transport
regulation of calcium ion-dependent exocytosis
regulation of endocytosis
cell differentiation
regulation of vesicle fusion
negative regulation of catecholamine secretion
negative regulation of calcium ion-dependent exocytosis
positive regulation of calcium ion-dependent exocytosis
negative regulation of short-term neuronal synaptic plasticity
negative regulation of protein secretion
calcium-dependent activation of synaptic vesicle fusion
dense core granule cytoskeletal transport
regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
regulation of postsynaptic dense core vesicle exocytosis
negative regulation of secretion by cell
positive regulation of dendrite extension
positive regulation of dense core granule exocytosis
negative regulation of retrograde trans-synaptic signaling by neuropeptide
negative regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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