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Invitrogen
VAV1 Polyclonal Antibody
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FIGURE: 1 / 3
VAV1 Antibody (PA5-118349) in ICC/IF
Immunofluorescence staining of VAV1 in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with VAV1 Polyclonal Antibody (Product # PA5-118349, 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.
Product Details
PA5-118349
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human VAV1 fragment
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: oncogene vav; Proto-oncogene vav; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene
Gene Aliases: VAV; VAV1
UniProt ID: (Human) P15498
Entrez Gene ID: (Human) 7409
immune response-regulating cell surface receptor signaling pathway
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell differentiation
neutrophil chemotaxis
T cell costimulation
intracellular signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
T cell activation
natural killer cell mediated cytotoxicity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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