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Invitrogen
Phospho-ETV6 (Ser257) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-ETV6 (Ser257) Antibody (PA5-118721) in IHC (P)
Immunohistochemical analysis of Phospho-ETV6 (Ser257) in Mouse brain tissue using a Phospho-ETV6 (Ser257) polyclonal antibody (Product # PA5-118721). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary... View More
Product Details
PA5-118721
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ETV6(Accession P41212), corresponding to amino acid residues around phosphorylated Ser257.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of ETV6 / Tel only when phosphorylated at Ser257.
Target Information
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and Maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGI-108; CSL4; Csl4p; ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV6-RUNX1 fusion protein; hCsl4p; p13; RP11-452K12.9; SKI4; Ski4p; t(5;12) translocation breakpoint occurs after nucleotide 487; Tel; TEL1 oncogene; Transcription factor ETV6; unnamed protein product
Gene Aliases: AW123102; AW557856; ETV6; TEL; TEL/ABL; TEL1; THC5
UniProt ID: (Human) P41212, (Mouse) P97360
Entrez Gene ID: (Human) 2120, (Mouse) 14011, (Rat) 312777
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
vitellogenesis
neurogenesis
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell proliferation
mesenchymal cell apoptotic process
transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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