Search

  • Contáctenos
  • Orden Rápida

Invitrogen

Phospho-ATP1A1 (Tyr260) Polyclonal Antibody

View all (39) ATP1A1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-ATP1A1 (Tyr260) Polyclonal Antibody

Product Details

PA5-118769

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ATP1A1(Accession P05023), corresponding to amino acid residues around phosphorylated Tyr260.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903269

Product Specific Information

Antibody detects endogenous levels of ATP1A1 only when phosphorylated at Tyr260.

Target Information

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; G00-119-711; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+ K+ ATPase alpha subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1; unnamed protein product

View more View less

Gene Aliases: ATP1A1; Atpa-1; BC010319; CMT2DD; HOMGSMR2; Nkaa1b

View more View less

UniProt ID: (Human) P05023, (Rat) P06685, (Mouse) Q8VDN2

View more View less

Entrez Gene ID: (Human) 476, (Rat) 24211, (Mouse) 11928

View more View less

Function(s)
nucleotide binding sodium:potassium-exchanging ATPase activity protein binding ATP binding potassium-transporting ATPase activity phosphatase activity ATPase activity potassium ion binding sodium ion binding ion channel binding metal ion binding protein heterodimerization activity chaperone binding steroid hormone binding protein kinase binding protein domain specific binding ankyrin binding ADP binding phosphatidylinositol 3-kinase binding hydrolase activity primary active transporter
Process(es)
regulation of the force of heart contraction regulation of sodium ion transport ion transport potassium ion transport sodium ion transport cellular sodium ion homeostasis osmosensory signaling pathway regulation of blood pressure response to xenobiotic stimulus establishment or maintenance of transmembrane electrochemical gradient cellular cation homeostasis cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process sodium ion transmembrane transport sodium ion export from cell negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction sodium ion homeostasis relaxation of cardiac muscle heart contraction cellular response to steroid hormone stimulus potassium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction hydrogen ion transmembrane transport response to glycoside potassium ion import across plasma membrane potassium ion import energy coupled proton transmembrane transport, against electrochemical gradient dephosphorylation response to drug cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus regulation of cardiac muscle cell contraction transport
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support