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Invitrogen
P2X2 Polyclonal Antibody
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FIGURE: 1 / 6
P2X2 Antibody (PA5-119683) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human esophagus tissue using P2X2 Polyclonal Antibody (Product # PA5-119683). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the P2X2 antibody at a dilution of... View More
Product Details
PA5-119683
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within C-terminal mouse P2X2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Mouse brain tissue lysates, rat brain tissue, human esophagus tissue, mouse brain tissue, MCF-7.
Subcellular Location: Cell membrane.
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP receptor; ligand-gated ion channel; ligand-gated ion channel; alternatively spliced; MGC129601; P2X ligand-gated ion channel; P2X purinoceptor 2; P2X Receptor, subunit 2; P2X2; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 2
Gene Aliases: DFNA41; P2RX2; P2X2; P2X2a
UniProt ID: (Human) Q9UBL9, (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Human) 22953, (Rat) 114115, (Mouse) 231602
nucleotide binding
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ion channel activity
ATP binding
ligand-gated ion channel activity
identical protein binding
copper ion binding
protein binding
drug binding
zinc ion binding
nickel cation binding
phosphatidylinositol binding
mercury ion binding
cadmium ion binding
cobalt ion binding
ligand-gated ion channel
response to hypoxia
response to ischemia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
ion transport
chemical synaptic transmission
neuromuscular synaptic transmission
neuromuscular junction development
sensory perception of sound
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
peristalsis
response to ATP
ion transmembrane transport
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
positive regulation of calcium-mediated signaling
sensory perception of taste
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
cation transport
response to organic substance
neuronal action potential
protein homooligomerization
protein heterooligomerization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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