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Invitrogen
SPTBN1 Polyclonal Antibody
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FIGURE: 1 / 5
SPTBN1 Antibody (PA5-119749) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human liver carcinoma tissue using SPTBN1 Polyclonal Antibody (Product # PA5-119749). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the SPTBN1 antibody at a d... View More
Product Details
PA5-119749
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human sptbn1 aa 2320-2364.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: SW1990 cell lysate, PANC-1 cell lysate, rat brain tissue lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, rat kidney tissue, human liver carcinoma tissue, mouse brain tissue.
Subcellular Location: Cell membrane, Cytoplasm, Cytoskeleton, Membrane.
Target Information
Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280 kDa alpha subunit and a 246 kDa beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e. g. beta-1 epsilon-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta fodrin; beta II spectrin-like (short form); beta-fodrin; beta-G spectrin; Beta-II spectrin; beta-spectrin 2; beta-spectrin 2, non-erythrocytic; beta-spectrin II; beta-spectrin non-erythrocytic 1; brain spectrin; bSPII-; cytoskeleton protein; embryonic liver beta-fodrin; Embryonic liver fodrin; embryonic liver fodrin beta chain; epididymis luminal protein 102; Fodrin beta chain; non-erythrocytic; non-erythroid spectrin beta; short form of beta II spectrin; spectrin beta 2; spectrin beta chain, brain 1; Spectrin beta chain, non-erythrocytic 1; spectrin G; Spectrin, non-erythroid beta chain 1; SPNB2; unnamed protein product
Gene Aliases: 9930031C03Rik; AL033301; betaSpII; DDISBA; ELF; elf1; elf3; HEL102; mKIAA4049; Spnb-2; Spnb1; Spnb2; SPTB2; SPTBN1
UniProt ID: (Human) Q01082, (Mouse) Q62261
Entrez Gene ID: (Human) 6711, (Rat) 305614, (Mouse) 20742
mitotic cytokinesis
plasma membrane organization
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
Golgi to plasma membrane protein transport
membrane assembly
protein targeting to plasma membrane
actin filament capping
positive regulation of interleukin-2 secretion
regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
central nervous system development
vesicle-mediated transport
central nervous system formation
actin cytoskeleton organization
positive regulation of interleukin-2 production
regulation of SMAD protein import into nucleus
protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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