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Invitrogen

HMGB2 Polyclonal Antibody

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HMGB2 Polyclonal Antibody

Product Details

PA5-119979

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within human HMGB2 aa 1-200.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913551

Product Specific Information

Positive Control: PC-12, SiHa, rat large intestine tissue, rat testis tissue, human tonsil tissue, human colon tissue, human colon carcinoma tissue, human spleen tissue, mouse kidney tissue.

Subcellular Location: Secreted, nucleus, chromosome, cytoplasm.

Target Information

HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: High mobility group protein 2; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 2; HMG 2; HMG B2; HMG-2; HMG-B2; HMGB-2; unnamed protein product

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Gene Aliases: C80539; HMG-2; HMG2; HMGB2

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UniProt ID: (Human) P26583, (Rat) P52925, (Mouse) P30681

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Entrez Gene ID: (Human) 3148, (Rat) 29395, (Mouse) 97165

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Function(s)
four-way junction DNA binding transcription regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding DNA binding, bending protein domain specific binding chemoattractant activity non-sequence-specific DNA binding, bending RAGE receptor binding supercoiled DNA binding DNA-binding transcription factor binding transcription factor activity, sequence-specific DNA binding lipid binding nucleosomal histone binding transcription regulatory region DNA binding poly(A) RNA binding chromatin binding
Process(es)
positive regulation of endothelial cell proliferation base-excision repair, DNA ligation chromatin remodeling regulation of transcription from RNA polymerase II promoter spermatogenesis spermatid nucleus differentiation nervous system development male gonad development organ regeneration positive regulation of nuclease activity positive regulation of DNA binding positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone positive chemotaxis positive regulation of DNA metabolic process cell chemotaxis cellular response to lipopolysaccharide negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of transcription from RNA polymerase II promoter immune system process inflammatory response to antigenic stimulus DNA topological change double-strand break repair via nonhomologous end joining DNA recombination chromatin organization nucleosome assembly chemotaxis inflammatory response extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression negative regulation of gene expression DNA geometric change response to lipopolysaccharide positive regulation of interferon-beta production V(D)J recombination innate immune response positive regulation of innate immune response regulation of neurogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium regulation of stem cell proliferation regulation of hemopoiesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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