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Invitrogen

p73 Polyclonal Antibody

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p73 Polyclonal Antibody

Product Details

PA5-120045

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 487-636 of human TP73 (NP_005418.1).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.07 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913617

Product Specific Information

Positive test controls include: 293T. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: YHADPSLVSF LTGLGCPNCI EYFTSQGLQS IYHLQNLTIE DLGALKIPEQ YRMTIWRGLQ DLKQGHDYST AQQLLRSSNA ATISIGGSGE LQRQRVMEAV HFRVRHTITI PNRGGPGGGP DEWADFGFDL PDCKARKQPI KEEFTEAEIH

Target Information

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; Tumor protein p73; unnamed protein product

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Gene Aliases: CILD47; deltaNp73; P73; TAp73; TP73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Mouse) 22062

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding identical protein binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding MDM2/MDM4 family protein binding DNA-binding transcription factor binding promoter-specific chromatin binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor binding transcription regulatory region DNA binding P53-like transcription factor
Process(es)
kidney development release of cytochrome c from mitochondria mismatch repair regulation of transcription, DNA-templated apoptotic process inflammatory response cellular response to DNA damage stimulus regulation of mitotic cell cycle negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus post-embryonic development regulation of gene expression hippocampus development forebrain development cerebrospinal fluid secretion intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process positive regulation of MAPK cascade regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of cell size positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract morphogenesis neuron development positive regulation of oligodendrocyte differentiation protein tetramerization regulation of cell cycle negative regulation of cardiac muscle cell proliferation positive regulation of lung ciliated cell differentiation positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity transcription, DNA-templated transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle cell cycle arrest response to X-ray response to gamma radiation mitotic G1 DNA damage checkpoint cellular response to UV negative regulation of JUN kinase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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