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Invitrogen
TRPV6 Polyclonal Antibody
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FIGURE: 1 / 2
TRPV6 Antibody (PA5-120426) in IHC (P)
Immunohistochemistry analysis of TRPV6 in paraffin-embedded rat stomach. Samples were incubated with TRPV6 Polyclonal antibody (Product # PA5-120426) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-120426
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRPV6 (NP_061116.5).
Conjugate
Form
Liquid
Concentration
1.65 mg/mL
Amount
165 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: 293T, PC-3. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: ESWAQSRDEQ NLLQ
Target Information
Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alu-binding protein with zinc finger domain; calcium permeable ion channel; Calcium transport protein 1; calcium transporter-like protein; calcium transporter/channel subtype 1; CaT-L; CaT-like; CaT1; ECaC2; epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; osmosensitive transient receptor potential channel 3; Transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily 5, member 6; TrpV6; unnamed protein product; zinc-finger protein p11
Gene Aliases: ABP/ZF; Cac; CAT; CAT1; CATL; ECAC2; HRPTTN; HSA277909; LP6728; Otrpc3; TRPV6; ZFAB
UniProt ID: (Human) Q9H1D0, (Rat) Q9R186, (Mouse) Q91WD2
Entrez Gene ID: (Human) 55503, (Rat) 114246, (Mouse) 64177
ion transport
calcium ion transport
regulation of calcium ion-dependent exocytosis
ion transmembrane transport
parathyroid hormone secretion
response to calcium ion
calcium ion homeostasis
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
calcium ion import
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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