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Invitrogen

Filamin A Polyclonal Antibody

View all (26) Filamin A antibodies

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Filamin A Polyclonal Antibody

Product Details

PA5-120445

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Amount

51 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914017

Product Specific Information

Positive test controls include: Jurkat, HeLa, NIH/3T3, 293T, U-251MG, Mouse lung. The target is usually found in the following locations: Cytoplasm, cell cortex, cytoskeleton.

Immunogen sequence: NQPASFAVSL NGAKGAIDAK VHSPSGALEE CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK IRVGEPGHGG DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID GPSKVKMDCQ ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT LVVKWGDEHI PGSPYRVVVP

Target Information

Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin; unnamed protein product

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Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; FGS2; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD

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UniProt ID: (Human) P21333, (Mouse) Q8BTM8

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Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176

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Function(s)
G-protein coupled receptor binding RNA binding actin binding protein binding potassium channel regulator activity kinase binding small GTPase binding Fc-gamma receptor I complex binding protein homodimerization activity ion channel binding macromolecular complex binding cadherin binding SMAD binding actin filament binding GTPase binding DNA-binding transcription factor binding protein sequestering activity glycoprotein binding signal transducer activity protein kinase C binding transcription factor binding Rho GTPase binding Ral GTPase binding mu-type opioid receptor binding protein complex binding poly(A) RNA binding Rac GTPase binding
Process(es)
epithelial to mesenchymal transition adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process actin cytoskeleton organization actin cytoskeleton reorganization protein localization to cell surface negative regulation of protein catabolic process cilium assembly mRNA transcription from RNA polymerase II promoter positive regulation of transcription factor import into nucleus receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity early endosome to late endosome transport establishment of protein localization protein stabilization cytoplasmic sequestering of protein actin crosslink formation platelet aggregation mitotic spindle assembly negative regulation of transcription from RNA polymerase I promoter cell projection organization negative regulation of apoptotic process positive regulation of substrate adhesion-dependent cell spreading positive regulation of integrin-mediated signaling pathway blood coagulation, intrinsic pathway positive regulation of platelet activation formation of radial glial scaffolds cerebral cortex development regulation of cell migration positive regulation of actin filament bundle assembly megakaryocyte development positive regulation of protein import into nucleus wound healing, spreading of cells release of sequestered calcium ion into cytosol cilium morphogenesis semaphorin-plexin signaling pathway protein localization to plasma membrane tubulin deacetylation establishment of Sertoli cell barrier positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction regulation of membrane repolarization during atrial cardiac muscle cell action potential regulation of membrane repolarization during cardiac muscle cell action potential positive regulation of neural precursor cell proliferation positive regulation of neuron migration
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