Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Reelin Polyclonal Antibody

View all (15) Reelin antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

PA5-120595

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.21 mg/mL

Amount

121 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914167

Product Specific Information

Positive test controls include: U-87MG, C6, LO2, HepG2.

Target Information

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: extracellular matrix serine protease; Reeler protein; Reelin; unnamed protein product

View more View less

Gene Aliases: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL

View more View less

UniProt ID: (Human) P78509, (Mouse) Q60841, (Rat) P58751

View more View less

Entrez Gene ID: (Human) 5649, (Mouse) 19699, (Rat) 24718

View more View less

Function(s)
peptidase activity serine-type peptidase activity hydrolase activity metal ion binding receptor agonist activity lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding protein binding molecular_function protein serine/threonine/tyrosine kinase activity cell adhesion molecule extracellular matrix glycoprotein extracellular matrix protein
Process(es)
cell morphogenesis neuron migration proteolysis cell adhesion axon guidance central nervous system development brain development learning long-term memory locomotory behavior associative learning glial cell differentiation regulation of gene expression positive regulation of neuron projection development dendrite development cell migration spinal cord patterning ventral spinal cord development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex cerebral cortex development forebrain development positive regulation of TOR signaling protein localization to synapse reelin-mediated signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of neuron differentiation response to pain regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of protein kinase B signaling positive regulation of synaptic transmission, glutamatergic regulation of synaptic activity long-term synaptic potentiation positive regulation of dendritic spine morphogenesis regulation of synapse maturation positive regulation of synapse maturation postsynaptic density assembly NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse motor neuron migration lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration interneuron migration positive regulation of excitatory postsynaptic potential regulation of neuron migration cell morphogenesis involved in differentiation multicellular organism development positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation dentate gyrus development positive regulation of CREB transcription factor activity thyroid hormone metabolic process positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein tyrosine kinase activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity midgut development memory response to mechanical stimulus response to toxic substance response to hormone response to lithium ion response to organic cyclic compound response to insecticide orbitofrontal cortex development hypothalamus development response to progesterone social behavior response to drug response to amino acid response to ethanol response to axon injury response to corticosterone response to electrical stimulus response to fatty acid cellular response to dexamethasone stimulus
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support