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Invitrogen
alpha Catenin Polyclonal Antibody
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FIGURE: 1 / 8
alpha Catenin Antibody (PA5-120932) in IHC (P)
Immunohistochemistry analysis of alpha Catenin in paraffin-embedded human vermiform appendix. Samples were incubated with alpha Catenin Polyclonal antibody (Product # PA5-120932) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-120932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human alpha-Catenin (NP_0018942)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Amount
36 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: BT-474, OVCAR3, 293T, MCF7, Mouse lung, Mouse heart, Mouse brain. The target is usually found in the following locations: Cell junction, Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, cytoskeleton.
Immunogen sequence: ELDDSDFETE DFDVRSRTSV QTEDDQLIAG QSARAIMAQL PQEQKAKIAE QVASFQEEKS KLDAEVSKWD DSGNDIIVLA KQMCMIMMEM TDFTRGKGPL KNTSDVISAA KKIAEAGSRM DKLGRTIADH CPDSACKQDL LAYLQRIALY CHQLNICSKV KAEVQNLGGE LVVSGVDSAM SLIQAAKNLM NAVVQTVKAS YVASTKYQKS QGMASLNLPA VSWKMKAPEK KPLVKREKQD ETQTKIKRAS QKKHVNPVQA LSEFKAMDSI
Target Information
Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 102 kDa cadherin-associated protein; alpha E catenin; Alpha E-catenin; Alpha N-catenin; alpha(E)-catenin; alpha(N)-catenin; alpha-catenin; Alpha-catenin-related protein; alpha-E-catenin; alpha-N-catenin; alphaE-catenin; alphaN-catenin; cadherin associated protein; Cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; CAP102; catenin; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; catenin alpha 1; catenin alpha 2; Catenin alpha-1; Catenin alpha-2; Catenin alpha1; Catenin alpha2; catenin, alpha 1; Catenin-alpha1; Catenin-alpha2; cerebellar deficient folia; epididymis secretory sperm binding protein; FLJ36832; FLJ52416; HGNC:2509; NY-REN-13 antigen; Renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: 2010010M04Rik; AA517462; AI481747; AI988031; CAP-R; CAP102; CAPR; Catna; Catna1; Catna2; CDCBM9; cdf; chp; CT114; CTNNA1; CTNNA2; CTNR; MDBS2; MDPT2
UniProt ID: (Human) P35221, (Human) P26232, (Mouse) P26231, (Mouse) Q61301
Entrez Gene ID: (Human) 1495, (Human) 1496, (Rat) 307505, (Mouse) 12385, (Mouse) 12386, (Rat) 297357
RNA binding
structural molecule activity
protein binding
beta-catenin binding
cytoskeletal protein binding
vinculin binding
identical protein binding
macromolecular complex binding
gamma-catenin binding
cadherin binding
actin filament binding
structural constituent of cytoskeleton
poly(A) RNA binding
non-motor actin binding protein
ovarian follicle development
apoptotic process
cell adhesion
establishment or maintenance of cell polarity
smoothened signaling pathway
integrin-mediated signaling pathway
neuroblast proliferation
negative regulation of neuroblast proliferation
protein localization
male gonad development
gap junction assembly
cell migration
axon regeneration
regulation of cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
cell motility
cellular response to indole-3-methanol
epithelial cell-cell adhesion
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
negative regulation of protein localization to nucleus
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
cytoskeleton organization
axonogenesis
regulation of neuron projection development
radial glia guided migration of Purkinje cell
cell differentiation
negative regulation of Arp2/3 complex-mediated actin nucleation
dendrite morphogenesis
brain morphogenesis
regulation of synapse structural plasticity
prepulse inhibition
modification of postsynaptic actin cytoskeleton
regulation of neuron migration
actin filament organization
aging
response to organic cyclic compound
cellular protein localization
protein heterooligomerization
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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