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Invitrogen
FGD4 Polyclonal Antibody
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FIGURE: 1 / 1
FGD4 Antibody (PA5-121213) in WB
Western blot analysis of FGD4 in extracts of various cell lines. Samples were incubated with FGD4 Polyclonal antibody (Product # PA5-121213) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-121213
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human FGD4 (NP_640334.2).
Conjugate
Form
Liquid
Concentration
2.58 mg/mL
Amount
258 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: U-87MG, HeLa, HepG2, A-549, Rat brain. The target is usually found in the following locations: Cell projection, Cytoplasm, cytoskeleton, filopodium.
Immunogen sequence: QMECEEEKAA TLSSDTSIQA SEPLLDTHIV NGERDETATA PASPTTDSCD GNASDSSYRT PGIGPVLPLE ERGAETETKV QERENGESPL ELEQLDQHHE
Target Information
The FGD4 gene, also known as FYVE, RhoGEF, and PH domain-containing protein 4, is located on chromosome 12p11.21. This gene encodes a protein involved in the regulation of the actin cytoskeleton and is crucial for cellular processes such as migration and adhesion. FGD4 is specifically associated with Charcot-Marie-Tooth disease type 4H (CMT4H), a rare autosomal recessive hereditary neuropathy characterized by early onset, progressive distal muscle weakness, scoliosis, and myelin outfoldings. Mutations in FGD4 result in disruptions of its function, leading to the clinical manifestations of CMT4H. Additionally, the gene has been implicated in cancer biology, with its expression correlating with aggressive phenotypes in some cancers and contributing to therapeutic resistances. The gene includes multiple exons and alternative splicing variants, underlining its broad functional implications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin filament-binding protein frabin; actin-filament binding protein frabin; alternatively spliced; FGD1 family, member 4; FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4; unnamed protein product; Zinc finger FYVE domain-containing protein 6
Gene Aliases: 9030023J02Rik; 9330209B17Rik; CMT4H; FGD4; FRABP; ZFYVE6
UniProt ID: (Human) Q96M96, (Rat) O88387, (Mouse) Q91ZT5
Entrez Gene ID: (Human) 121512, (Rat) 246174, (Mouse) 224014
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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