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Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody

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Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody

Product Details

PA5-121361

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Amount

26 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914933

Product Specific Information

Positive test controls include: C6.

Immunogen sequence: MTGYV

Target Information

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; ERK-6; Extracellular signal-regulated kinase 6; MAP kinase 11; MAP kinase 12; MAP kinase 13; MAP kinase 14; MAP kinase 2; MAP kinase MXI2; MAP kinase p38 alpha; MAP kinase p38 beta; MAP kinase p38 delta; MAP kinase p38 gamma; MAP kinase p38-2; MAPK 12; MAPK 13; MAPK 14; MAPK11; MAPK12; MAPK13; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase 12; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38 beta; Mitogen-activated protein kinase p38 delta; Mitogen-activated protein kinase p38 gamma; mitogen-activated protein kinase p38-2; p38 MAP kinase; p38 mitogen activated protein kinase; p38-2; p38-delta MAPK; p38alpha Exip; reactive kinase; SAP kinase-3; SAPK2a; SAPK2a; CSAIDS binding protein 1; SAPK2b; SAPK4; splicing isoform of p38Beta MAP Kinase; Stress-activated protein kinase 2a; Stress-activated protein kinase 2b; Stress-activated protein kinase 3; Stress-activated protein kinase 4; stress-activated protein kinase-2; stress-activated protein kinase-2b; unnamed protein product

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Gene Aliases: CRK1; CSBP; CSBP1; CSBP2; CSPB1; ERK-6; ERK3; ERK6; EXIP; Hog; MAPK 12; MAPK 13; MAPK-13; MAPK11; MAPK12; MAPK13; MAPK14; MXI2; p38; p38-2; p38ALPHA; P38B; p38Beta; P38BETA2; p38delta; P38GAMMA; p38Hog; PRKM11; PRKM12; PRKM13; PRKM14; PRKM15; RK; SAPK-3; SAPK2; SAPK2A; SAPK2B; SAPK3; SAPK4

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UniProt ID: (Human) Q15759, (Human) P53778, (Human) O15264, (Human) Q16539, (Rat) Q63538

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Entrez Gene ID: (Human) 5600, (Human) 6300, (Human) 5603, (Human) 1432, (Rat) 689314, (Rat) 60352, (Rat) 29513, (Rat) 81649

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding kinase activity transferase activity protein serine kinase activity magnesium ion binding peptidase activator activity metal ion binding MAP kinase kinase activity enzyme binding protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein C-terminus binding non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade osteoblast differentiation positive regulation of gene expression stress-activated protein kinase signaling cascade positive regulation of interleukin-12 production intracellular signal transduction p38MAPK cascade positive regulation of erythrocyte differentiation positive regulation of muscle cell differentiation stress-activated MAPK cascade protein maturation cardiac muscle cell proliferation regulation of cardiac muscle cell proliferation negative regulation of cardiac muscle cell proliferation bone development pyroptosis cellular response to interleukin-1 cellular response to UV-B cellular senescence cellular response to virus NLRP1 inflammasome complex assembly signal transduction muscle organ development cellular response to stress signal transduction in response to DNA damage myoblast differentiation negative regulation of cell cycle regulation of cell cycle response to osmotic stress positive regulation of interleukin-6 production cellular response to UV positive regulation of inflammatory response cellular response to hydrogen peroxide cellular response to sorbitol cellular response to anisomycin cellular response to sodium arsenite DNA damage checkpoint cell morphogenesis cartilage condensation angiogenesis placenta development response to dietary excess chondrocyte differentiation negative regulation of inflammatory response to antigenic stimulus glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process chemotaxis cellular response to DNA damage stimulus cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development positive regulation of myotube differentiation fatty acid oxidation platelet activation regulation of ossification osteoclast differentiation positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide response to insulin tumor necrosis factor-mediated signaling pathway negative regulation of hippo signaling cellular response to vascular endothelial growth factor stimulus response to muscle stretch positive regulation of protein import into nucleus positive regulation of blood vessel endothelial cell migration positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter glucose import positive regulation of glucose import vascular endothelial growth factor receptor signaling pathway stem cell differentiation striated muscle cell differentiation positive regulation of cardiac muscle cell proliferation 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to tumor necrosis factor cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation stress-induced premature senescence regulation of synaptic membrane adhesion regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion positive regulation of reactive oxygen species metabolic process protein phosphorylation transcription, DNA-templated peptidyl-serine phosphorylation response to glucose myoblast differentiation involved in skeletal muscle regeneration protein autophosphorylation
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