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Invitrogen
BRCA2 Polyclonal Antibody
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Product Details
PA5-122189
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Lys2308-His2537 (Accession P51587), with N-terminal His Tag
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; BRCA2 DNA repair associated protein; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; Breast cancer type 2 susceptibility protein; DNA repair associated; DNA repair-associated BRCA2; FANCB; Fanconi anemia group D1 protein; mutant BRCA2; mutant DNA repair-associated protein 2; RP11-298P3.4
Gene Aliases: BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11
UniProt ID: (Human) P51587
Entrez Gene ID: (Human) 675
telomere maintenance via recombination
double-strand break repair via homologous recombination
oocyte maturation
inner cell mass cell proliferation
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
chromatin remodeling
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
male meiosis I
spermatogenesis
brain development
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
DNA damage response, signal transduction by p53 class mediator
replication fork processing
regulation of cytokinesis
negative regulation of mammary gland epithelial cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
chromosome organization
centrosome duplication
establishment of protein localization to telomere
hematopoietic stem cell proliferation
cellular response to ionizing radiation
stem cell proliferation
cellular senescence
mitotic recombination-dependent replication fork processing
regulation of DNA damage checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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