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Invitrogen
CaMKII delta Polyclonal Antibody
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FIGURE: 1 / 3
CaMKII delta Antibody (PA5-14036) in IHC (P)
Immunohistochemistry analysis of CaMKII delta in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with CaMKII delta polyclonal antibody (Product # PA5-14036) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcin... View More
Product Details
PA5-14036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 448-478 amino acids from the C-terminal region of human CAMK2D (CAMK2 delta)
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Amount
192 µg
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse, porcine and rabbit based on sequence homology.
Target Information
CaMKII delta belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Calcium, calmodulin-dependent protein kinase, type II; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CAM2; CaMK-II delta subunit; caMK-II subunit delta; CAMK2B; CAMK2G; CAMKB; CAMKG; unnamed protein product
Gene Aliases: CAMK1; Camk2; CAMK2D; CAMKD; Camki; RATCAMKI
UniProt ID: (Human) Q13557, (Rat) P15791
Entrez Gene ID: (Human) 817, (Rat) 24246
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
sodium channel inhibitor activity
titin binding
identical protein binding
protein homodimerization activity
ion channel binding
protein serine kinase activity
nitric-oxide synthase binding
non-receptor serine/threonine protein kinase
regulation of cell growth
regulation of the force of heart contraction
regulation of membrane depolarization
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
regulation of heart contraction
positive regulation of cardiac muscle hypertrophy
regulation of cell communication by electrical coupling
positive regulation of cardiac muscle cell apoptotic process
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
endoplasmic reticulum calcium ion homeostasis
regulation of neuronal synaptic plasticity
relaxation of cardiac muscle
long-term synaptic potentiation
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cellular localization
cellular response to calcium ion
cardiac muscle cell contraction
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of relaxation of cardiac muscle
negative regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of protein localization to plasma membrane
G1/S transition of mitotic cell cycle
response to hypoxia
regulation of sodium ion transport
calcium ion transport
regulation of G2/M transition of mitotic cell cycle
positive regulation of smooth muscle cell migration
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cellular potassium ion homeostasis
positive regulation of Rac protein signal transduction
protein autophosphorylation
positive regulation of smooth muscle cell proliferation
protein oligomerization
cardiac muscle contraction
cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
negative regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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