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Invitrogen
SRD5A1 Polyclonal Antibody
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FIGURE: 1 / 3
SRD5A1 Antibody (PA5-142456) in IHC (P)
Immunohistochemistry analysis of SRD5A1 in human small intestine. Samples were incubated with SRD5A1 polyclonal antibody (Product # PA5-142456) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-142456
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-RNLRKPGDTGYK (aa 173-184).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; S5AR 1; SR type 1; steroid 5-alpha-reductase (EC 1.3.99.5); Steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); unnamed protein product
Gene Aliases: S5AR 1; SRD5A1
UniProt ID: (Human) P18405
Entrez Gene ID: (Human) 6715
urogenital system development
liver development
lipid metabolic process
steroid biosynthetic process
androgen biosynthetic process
androgen catabolic process
sex determination
sex differentiation
steroid metabolic process
androgen metabolic process
male gonad development
cellular response to starvation
response to xenobiotic stimulus
response to muscle activity
diterpenoid metabolic process
spinal cord development
hippocampus development
thalamus development
hypothalamus development
pituitary gland development
cerebral cortex development
cell differentiation
male genitalia development
female genitalia development
response to follicle-stimulating hormone
response to estradiol
cellular response to insulin stimulus
response to testosterone
serotonin metabolic process
progesterone metabolic process
response to estrogen
bone development
response to growth hormone
response to fungicide
cellular response to cAMP
cellular response to growth factor stimulus
cellular response to estradiol stimulus
cellular response to testosterone stimulus
cellular response to dexamethasone stimulus
cellular response to epinephrine stimulus
cellular response to serotonin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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