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Invitrogen
ZIC2 Polyclonal Antibody
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FIGURE: 1 / 1
ZIC2 Antibody (PA5-142713) in WB
Western Blot analysis of ZIC2 in RWPE1 lysate (60 µg protein in RIPA buffer) overexpressing Human ZIC2 with C-terminal MYC tag using ZIC2 Polyclonal Antibody (Product # PA5-142713) at 0.5 µg/mL in the right panel and probed with anti-MYC Tag (1:1,000) and anti-beta-Actin in the left panel. Mock-transfected RWPE1 in lanes 1 and expressing GFP in lanes 2. Primary incubations were overnight at 4°C. Detected by chemiluminescence.
Product Details
PA5-142713
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-HSGLSSNFNEWY.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to NOT cross-react with other ZIC proteins.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: transcription factor; Zic family member 2 (odd-paired homolog, Drosophila); Zinc finger protein of the cerebellum 2; Zinc finger protein ZIC 2
Gene Aliases: HPE5; ZIC2
UniProt ID: (Human) O95409
Entrez Gene ID: (Human) 7546
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
chromatin DNA binding
metal ion binding
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
brain development
visual perception
cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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