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Invitrogen

PTCH Polyclonal Antibody

View all (41) PTCH antibodies

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PTCH Polyclonal Antibody

Product Details

PA5-142733

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

8 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-EELKKINYQVDSWEE.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2933379

Product Specific Information

Additional Information: This antibody is expected to recognize all reported isoforms (NP_000255.2; NP_001077072.1; NP_001077071.1; NP_001077073.1).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched gene homolog; similar to Drosophila patched protein, Swiss-Prot Accession Number P18502; transmembrane protein; Method: conceptual translation supplied by author; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; Ptch1 protein +12b; RP11-435O5.3; unnamed protein product

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Gene Aliases: A230106A15Rik; BCNS; BCNS1; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; SLC65B1

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UniProt ID: (Human) Q13635, (Mouse) Q61115

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Entrez Gene ID: (Human) 5727, (Mouse) 19206

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Function(s)
patched binding smoothened binding protein binding hedgehog receptor activity heparin binding cholesterol binding cyclin binding macromolecular complex binding hedgehog family protein binding zinc ion binding protein complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis in utero embryonic development cell fate determination neural tube formation neural tube closure heart morphogenesis signal transduction spermatid development regulation of mitotic cell cycle pattern specification process brain development negative regulation of cell proliferation epidermis development regulation of smoothened signaling pathway response to xenobiotic stimulus response to mechanical stimulus organ morphogenesis dorsal/ventral pattern formation epidermal cell fate specification response to chlorate negative regulation of keratinocyte proliferation positive regulation of cholesterol efflux protein processing spinal cord motor neuron differentiation neural tube patterning dorsal/ventral neural tube patterning neural plate axis specification embryonic limb morphogenesis prostate gland development mammary gland development response to estradiol response to retinoic acid regulation of protein localization limb morphogenesis hindlimb morphogenesis regulation of growth negative regulation of multicellular organism growth regulation of cell proliferation glucose homeostasis response to alkaloid keratinocyte proliferation positive regulation of epidermal cell differentiation negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated embryonic organ development smooth muscle tissue development epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of cell division pharyngeal system development mammary gland duct morphogenesis mammary gland epithelial cell differentiation cell differentiation involved in kidney development somite development cellular response to cholesterol commissural neuron axon guidance stem cell proliferation cell proliferation involved in metanephros development metanephric collecting duct development protein localization to plasma membrane liver regeneration negative regulation of stem cell proliferation smoothened signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity smoothened signaling pathway involved in dorsal/ventral neural tube patterning protein targeting to plasma membrane
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