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Invitrogen

JNK2 beta Polyclonal Antibody

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Product Details

PA5-142861

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-EMVLHKVLFPGRDY.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2933504

Product Specific Information

Additional Information: This antibody is expected to recognize isoforms beta1 and beta 2 (NP_620708.1; NP_620709.1).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK/SAPK alpha; Jun kinase; MAP kinase 9; MAPK 9; MAPK9; mitogen activated protein kinase 9; Mitogen-activated protein kinase 9; protein kinase, mitogen-activated 9; SAPK1a; Stress-activated protein kinase 1a; Stress-activated protein kinase JNK2; unnamed protein product

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Gene Aliases: AI851083; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; MAPK9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1A

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UniProt ID: (Human) P45984, (Mouse) Q9WTU6

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Entrez Gene ID: (Human) 5601, (Mouse) 26420

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein serine kinase activity transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process transferase activity, transferring phosphorus-containing groups mitogen-activated protein kinase kinase kinase binding non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade protein phosphorylation JNK cascade positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to reactive oxygen species Fc-epsilon receptor signaling pathway regulation of circadian rhythm regulation of mRNA stability response to cadmium ion rhythmic process modulation of synaptic transmission mRNA destabilization protein localization to tricellular tight junction positive regulation of podosome assembly cellular senescence inflammatory response to wounding apoptotic signaling pathway positive regulation of cytokine production involved in inflammatory response positive regulation of apoptotic signaling pathway release of cytochrome c from mitochondria positive regulation of protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process JUN phosphorylation positive regulation of cell morphogenesis involved in differentiation phosphorylation neuron projection development positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV response to drug positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade positive regulation of nitric-oxide synthase biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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