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Invitrogen
MUSK Polyclonal Antibody
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FIGURE: 1 / 5
MUSK Antibody (PA5-14703) in IHC (P)
Immunohistochemistry analysis of MUSK in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with MUSK polyclonal antibody (Product # PA5-14703) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-14703
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human MUSK
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Amount
560 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126323; MGC126324; Muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
Gene Aliases: CMS9; FADS; FADS1; MUSK
UniProt ID: (Human) O15146
Entrez Gene ID: (Human) 4593
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of macromolecule metabolic process
positive regulation of gene expression
cell differentiation
skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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