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Invitrogen
Cytochrome P450 Reductase Polyclonal Antibody
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Product Details
PA5-149184
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived human POR/Cytochrome P450 Reductase, Arg45-Ser677
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCR; CPR; CY DKFZp686G04235; cytochrome P450 reductase; DKFZp686G04235; FLJ26468; NADPH Cytochrome; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450 Reductase; P450R; unnamed protein product
Gene Aliases: 4933424M13Rik; CPR; CYPOR; P450R; POR
UniProt ID: (Human) P16435, (Rat) P00388, (Mouse) P37040
Entrez Gene ID: (Human) 5447, (Rat) 29441, (Mouse) 18984
NADPH-hemoprotein reductase activity
cytochrome-b5 reductase activity, acting on NAD(P)H
protein binding
enzyme activator activity
nitric oxide dioxygenase activity
electron carrier activity
FMN binding
oxidoreductase activity
hydrolase activity
enzyme binding
iron-cytochrome-c reductase activity
flavin adenine dinucleotide binding
NADP binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase
xenobiotic metabolic process
nitric oxide biosynthetic process
response to nutrient
response to xenobiotic stimulus
carnitine metabolic process
response to hormone
flavonoid metabolic process
fatty acid oxidation
electron transport chain
positive regulation of chondrocyte differentiation
negative regulation of apoptotic process
nitrate catabolic process
positive regulation of smoothened signaling pathway
nitric oxide catabolic process
positive regulation of growth plate cartilage chondrocyte proliferation
demethylation
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
response to dexamethasone
positive regulation of steroid hormone biosynthetic process
cellular organofluorine metabolic process
regulation of growth plate cartilage chondrocyte proliferation
internal peptidyl-lysine acetylation
positive regulation of monooxygenase activity
response to drug
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cholesterol biosynthetic process
oxidation-reduction process
negative regulation of lipase activity
regulation of cholesterol metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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