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Invitrogen
PMP70 Polyclonal Antibody
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Product Details
PA5149517
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ABCD3
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEGYIYSHCR KVGITLFTVS HRKSLWKHHE YYLHMDGRGN YEFKQITEDT VEFGS
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum" disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa peroxisomal membrane protein; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); peroxisomal membrane protein 70 kDa; Peroxisomal membrane protein-1 (70kD); PMP70; unnamed protein product
Gene Aliases: ABC43; ABCD3; CBAS5; PMP70; PXMP1; ZWS2
UniProt ID: (Human) P28288
Entrez Gene ID: (Human) 5825
nucleotide binding
long-chain fatty acid transporter activity
protein binding
ATP binding
hydrolase activity
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
protein homodimerization activity
acyl-CoA hydrolase activity
ABC-type transporter activity
very long-chain fatty acid metabolic process
fatty acid biosynthetic process
fatty acid beta-oxidation
bile acid biosynthetic process
lipid transport
peroxisome organization
response to xenobiotic stimulus
bile acid and bile salt transport
peroxisomal long-chain fatty acid import
very long-chain fatty acid catabolic process
transmembrane transport
phytanic acid metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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