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Invitrogen
DVL1 Polyclonal Antibody
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FIGURE: 1 / 7
DVL1 Antibody (PA5149782) in IHC (P)
Immunohistochemistry analysis of DVL1 in paraffin-embedded Mouse Cerebrum tissue; (Control: PBS). Samples were incubated with DVL1 Polyclonal (Product # PA5149782) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149782
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Dishevelled, Dsh Homolog 1 (DVL1) (Arg150-Lys285)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1; unnamed protein product
Gene Aliases: DRS2; DVL; DVL1; DVL1L1; DVL1P1; mKIAA4029
UniProt ID: (Human) O14640, (Mouse) P51141
Entrez Gene ID: (Human) 1855, (Mouse) 13542
heart looping
outflow tract morphogenesis
regulation of transcription, DNA-templated
neurotransmitter secretion
axonogenesis
axon guidance
neuromuscular junction development
positive regulation of neuron projection development
Wnt signaling pathway
synaptic vesicle exocytosis
neural tube development
convergent extension involved in neural plate elongation
cytoplasmic microtubule organization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
protein localization to nucleus
social behavior
protein localization to microtubule
intracellular signal transduction
non-canonical Wnt signaling pathway
receptor clustering
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting
axon extension
dendrite morphogenesis
synapse organization
protein stabilization
convergent extension involved in organogenesis
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
prepulse inhibition
dendritic spine morphogenesis
skeletal muscle acetylcholine-gated channel clustering
cochlea morphogenesis
presynapse assembly
postsynapse organization
regulation of postsynapse organization
positive regulation of neuron projection arborization
positive regulation of protein localization to presynapse
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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