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Invitrogen
Endothelin 2 Polyclonal Antibody
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FIGURE: 1 / 1
Endothelin 2 Antibody (PA5150131) in IHC (P)
Immunohistochemistry analysis of Endothelin 2 in paraffin-embedded Human Liver tissue. Samples were incubated with Endothelin 2 Polyclonal (Product # PA5150131) antibody using a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5150131
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Endothelin 2 (EDN2) (Gln32-Arg178)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDN 2; EDN-2; Endothelin-2; ET-2; PP ET-2; PPET2; preproendothelin 2; Preproendothelin-2
Gene Aliases: EDN2; ET-2; ET2; PPET2
UniProt ID: (Human) P20800
Entrez Gene ID: (Pig) 102157561, (Human) 1907
angiogenesis
temperature homeostasis
vasculature development
positive regulation of leukocyte chemotaxis
hormonal regulation of the force of heart contraction
positive regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
cellular calcium ion homeostasis
smooth muscle contraction
cell surface receptor signaling pathway
positive regulation of cell proliferation
cell tip growth
positive regulation of heart rate
artery smooth muscle contraction
vein smooth muscle contraction
cytokine-mediated signaling pathway
regulation of vasoconstriction
neutrophil chemotaxis
neuron projection development
positive regulation of prostaglandin biosynthetic process
macrophage activation
vasoconstriction
endothelial cell migration
positive regulation of smooth muscle contraction
macrophage chemotaxis
lung alveolus development
axon extension
positive regulation of calcium-mediated signaling
endothelin receptor signaling pathway
energy homeostasis
regulation of blood vessel diameter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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