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Invitrogen
GLT-1 Polyclonal Antibody
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FIGURE: 1 / 8
GLT-1 Antibody (PA5-17099) in WB
Western blot was performed using Anti-GLT-1 Polyclonal Antibody, (Product # PA5-17099) and band at ~55 kDa corresponding to GLT-1 was observed in Mouse and Rat Brain and Cerebellum but not in Kidney and Lung which are reported to be negative. Tissue extracts (30 µg lysate) of Mouse Brain (Lane 1), Mouse Cerebellum (Lane 2), Mouse Kidney (Lane 3), Mouse Lung (Lane 4), Rat Brain (Lane 5), Rat Cerebellum (Lane 6), Rat Kidney (Lane 7) and Rat Lung (Lane 8) were electrophoresed using Novex® NuPAGE® 4-12% % Bis-Tris gel (Product # NP0322BOX). Re... View More
Product Details
PA5-17099
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human EAAT2
Conjugate
Form
Liquid
Concentration
22 µg/mL
Amount
2.2 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EAAT2; EAAT2 variant mEAAT2/5UT5; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1a; GLT1b; GLT1c; GLUT-R; glutamate transporter 1c; glutamate transporter-1; Glutamate/aspartate transporter II; high affinity glucose transporter; human brain glutamate transporter; OTTHUMP00000165209; OTTHUMP00000165210; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2; unnamed protein product
Gene Aliases: 1700091C19Rik; 2900019G14Rik; AI159670; DEE41; EAAT2; EIEE41; Glt; GLT-1; GLT1; HBGT; MGLT1; SLC1A2
UniProt ID: (Human) P43004, (Mouse) P43006, (Rat) P31596
Entrez Gene ID: (Human) 6506, (Mouse) 20511, (Rat) 29482
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
anion transmembrane transporter activity
neutral amino acid transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
metal ion binding
sodium:dicarboxylate symporter activity
primary active transporter
glutathione biosynthetic process
ion transport
neurotransmitter transport
amino acid transport
chemical synaptic transmission
nervous system development
visual behavior
response to xenobiotic stimulus
response to light stimulus
response to wounding
neutral amino acid transport
L-glutamate transport
telencephalon development
adult behavior
multicellular organism growth
response to amino acid
positive regulation of glucose import
protein homotrimerization
transepithelial transport
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
anion transmembrane transport
import into cell
L-glutamate import across plasma membrane
neurotransmitter reuptake
L-aspartate import across plasma membrane
transport across blood-brain barrier
cysteine transmembrane transport
transport
dicarboxylic acid transport
multicellular organism aging
cellular response to extracellular stimulus
sodium ion transmembrane transport
response to drug
L-glutamate import
L-glutamate transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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