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Invitrogen
TRRAP Polyclonal Antibody
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Product Details
PA5-17187
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the human TRRAP protein
Conjugate
Form
Liquid
Concentration
125.4 µg/mL
Amount
12.54 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TRRAP is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. TRRAP plays a central role in MYC transcription activation, and also participates in cell transformation by MYC is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. TRRAP probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation, however, it is probably not required in the steps following histone acetylation in processes of transcription activation. TRRAP may be required for the mitotic checkpoint and normal cell cycle progression. TRRAP is a component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 350/400 kDa PCAF-associated factor; OTTHUMP00000197294; OTTHUMP00000197295; PAF350/400; similar to ATM/DNA-PK; STAF40; Tra1 homolog; transactivation/transformation-domain associated protein; Transformation/transcription domain-associated protein
Gene Aliases: AI481500; DEDDFA; DFNA75; PAF350/400; PAF400; STAF40; TR-AP; Tra1; TRRAP
UniProt ID: (Human) Q9Y4A5
Entrez Gene ID: (Human) 8295, (Mouse) 100683
transcription cofactor activity
protein binding
kinase activity
chromatin binding
transcription coactivator activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
non-receptor serine/threonine protein kinase
protein modifying enzyme
regulation of DNA repair
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of apoptotic process
regulation of RNA splicing
positive regulation of transcription, DNA-templated
regulation of cell cycle
regulation of cellular response to stress
DNA repair-dependent chromatin remodeling
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
DNA repair
transcription, DNA-templated
mitotic cell cycle checkpoint
phosphorylation
chromatin modification
histone deubiquitination
histone H4 acetylation
histone H2A acetylation
regulation of nucleic acid-templated transcription
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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