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Invitrogen
p38 MAPK gamma Polyclonal Antibody
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FIGURE: 1 / 4
p38 MAPK gamma Antibody (PA5-17371) in WB
Western blot was performed using Anti-p38 MAPK gamma Polyclonal Antibody (Product # PA5-17371) and a 41kDa band corresponding to Mitogen-activated protein kinase 12 was observed in Mouse Skeletal muscle and Rat Skeletal Muscle, but not in the other tested tissues. Whole cell extracts (30 µg lysate) of Mouse Thymus (Lane 1), Mouse Liver (Lane 2), Mouse Skeletal Muscle (Lane 3), Rat Liver (Lane 4), Rat Kidney (Lane 5), Rat Brain (Lane 6), Rat Skeletal Muscle (Lane 7) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP03... View More
Product Details
PA5-17371
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the carboxy-terminal residues of human p38 MAPK gamma.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with the other p38 MAPK isoforms p38-alpha, --beta or --delta.
Target Information
MAPK12 (p38 gamma) is a serine/threonine kinase involved in many different cellular processes. It is activated during hypoxia and gamma-irradiation-induced G(2) arrest. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. MAPK12 functions as a signal transducer during differentiation of myoblasts to myotubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK-6; ERK5; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; MAPK12; mitogen activated protein kinase 12; Mitogen-activated protein kinase 12; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; OTTHUMP00000196671; SAP kinase-3; stress activated protein kinase 3; Stress-activated protein kinase 3; unnamed protein product
Gene Aliases: AW123708; ERK-6; ERK3; ERK6; MAPK 12; MAPK12; P38GAMMA; PRKM12; SAPK-3; SAPK3
UniProt ID: (Human) P53778, (Rat) Q63538, (Mouse) O08911
Entrez Gene ID: (Human) 6300, (Rat) 60352, (Mouse) 29857
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
peptidase activator activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
signal transduction
muscle organ development
cellular response to stress
intracellular signal transduction
signal transduction in response to DNA damage
myoblast differentiation
negative regulation of cell cycle
positive regulation of muscle cell differentiation
regulation of cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
peptidyl-serine phosphorylation
cell cycle
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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