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Invitrogen
Phospho-NFkB p100 (Ser866, Ser870) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-NFkB p100 (Ser866, Ser870) Antibody (PA5-17385) in WB
Western blot analysis of Phospho-NF-kappa B2 p100 pSer866/870 in extracts from HeLa cells transfected with wild-type or mutant NF-kappaB2 p100 (SS866/870AA) using Phospho-NF-kappa B2 p100 pSer866/870 polyclonal antibody (Product # PA5-17385).
Product Details
PA5-17385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding serines 866/870 of NFkB2 p100 (homologous to pSer864/pSer868 of rat and pSer865/pSer869 of mouse)
Conjugate
Form
Liquid
Concentration
64 µg/mL
Amount
6.4 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Lyt10; NF kappaB2; NF-kB p100; NFKB, p52/p100 subunit; NFKB2 p100 subunit; nuclear factor Kappa-B, subunit 2; Nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; Oncogene Lyt-10; p50-NF-kappa B homolog; transcription factor NFKB2; unnamed protein product
Gene Aliases: CVID10; H2TF1; lyt; LYT-10; LYT10; NF-kappaB2; NF-kB2; NFKB2; p100; p49; p49/p100; p50B; p52
UniProt ID: (Human) Q00653, (Mouse) Q9WTK5
Entrez Gene ID: (Human) 4791, (Mouse) 18034
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
Rel homology transcription factor
follicular dendritic cell differentiation
germinal center formation
regulation of transcription, DNA-templated
signal transduction
I-kappaB kinase/NF-kappaB signaling
extracellular matrix organization
response to lipopolysaccharide
response to cytokine
NIK/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
spleen development
intracellular signaling cassette
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
innate immune response
lymph node development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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